Hazards of low dose methotrexate

Low dose Methotrexate for the treatment of generalized lichen planus

Background: Lichen planus is a common inflammatory disease that can involve the skin, nails, mucous membrane, and hair follicles. There is a long list of topical and systemic therapies for its treatment. Methotrexarte has some characteristics that make it a good choice for generalized lichen planus. Aim: The goal of this study was to assess the effect of low dose methotrexate in generalized lic...

Low-dose methotrexate in myeloproliferative neoplasm models.

Adverse effects of low dose methotrexate in rheumatoid arthritis patients.

OBJECTIVE To determine the frequency of adverse effects attributed to Methotrexate (MTX) toxicity and serum minimum toxic concentration with low dose MTX in Rheumatoid Arthritis (RA) patients. STUDY DESIGN Cross-sectional observational study. PLACE AND DURATION OF STUDY Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from March 2010 to Ma...

The Effect of Low Dose Methotrexate on Fracture Healing

Introduction Low dose methotrexate treatment (10-25 mg./week) is today considered the first choice disease-modifying agent (DMARD) for adult and juvenile rheumatoid arthritis. Methotrexate (MTX) has proven to be a safe and effective drug with relatively few side effects. Being a folate antagonist, MTX was originally designed for use in the treatment of malignancy. From the oncological practice,...

Low-dose methotrexate enhances cycling of highly anaplastic cancer cells

We previously showed that cellular RedOx state governs the G1-S transition of AH130 hepatoma, a tumor spontaneously reprogrammed to the embryonic stem cell stage. This transition is impaired when the mithocondrial electron transport system is blocked by specific inhibitors (antimycin A) or the respiratory chain is saturated by adding to the cells high concentrations of pyruvate. The antimycin A...